Our Science

Explore the Science Behind SAPRA™

Our newly published whitepaper presents comprehensive research supporting the efficacy and safety of Vision Protection Therapy™.

Drawing from decades of clinical use and laboratory studies, the paper outlines the science, methodology, and transformative potential of this non-damaging, repeatable therapy for treating progressive retinal diseases. It offers valuable insights for clinicians, researchers, and anyone interested in the future of vision care.

Download the whitepaper to dive into the data and discover how SAPRA™ is shaping the next frontier in retinal treatment.

Whitepaper

Thermal Adaptive Hormesis

Laser Induced Heat Shock
Applies a thermal heat shock using sublethal pulsed laser
Spike in Misguided Protein
Induces a sudden but nonlethal increase in concentration of misfolded proteins
Heat Shock Protein Activation
Activates Heat Shock Protein 70 (HSP 70) to accelerate protein repair of sick and dysfunctional cells
Normalized Cell Function
Activates Heat Shock Protein 70 (HSP 70) to accelerate protein repair of sick and dysfunctional cells

Key Clinical Publications

Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser

Clinical Ophthalmology 2020
14 2983–2993

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Vision protection therapy for prevention of neovascular age‑related macular degeneration

Nature (2023)
13:16710

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Low incidence of choroidal neovascularization following subthreshold diode micropulse laser (SDM) in high-risk AMD

PLoS ONE13(8)
e0202097

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Functionally Guided Retinal Protective Therapy for Dry Age-Related Macular and Inherited Retinal Degenerations: A Pilot Study

Invest Ophthalmol Vis Sci. 2016
57:265–275. DOI:10.1167/ iovs.15-18163
16 1555–1568

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Laser Resensitization of Medically Unresponsive Neovascular Age-Related Macular Degeneration (2014)

RETINA
0:1–11, 2014 16 1555–1568

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Real World Data Comparison of Standard Care vs SDMLaser Vision Protection Therapy for Prevention of Neovascular AMD

Clinical Ophthalmology 2022
16 1555–1568

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