Our Science

Explore the Science Behind SAPRA™

Our newly published whitepaper presents comprehensive research supporting the efficacy and safety of SAPRA™-applied SDM™ Vision Protection Therapy™.

Drawing from decades of clinical use and laboratory studies, the paper outlines the science, methodology, and transformative potential of this non-damaging, repeatable therapy for treating progressive retinal diseases. It offers valuable insights for clinicians, researchers, and anyone interested in the future of vision care.

Download the whitepaper to dive into the data and discover how SAPRA™ is shaping the next frontier in retinal treatment.

Whitepaper

Meet SAPRA™

Specialized
Reduced Risk
Ease of Operation
Patient Comfort

SAPRA™ is the first device designed perform modern retinal laser therapy, epitomized by SDM™ Vision Protection Therapy™

Treatment is non-invasive and safe; Locked parameters and built-in redundancies to further eliminate risk of harm from incorrect use

Simple & intuitive GUI and industrial design eliminates non-core elements of traditional lasers enabling providers to treat using SAPRA™ after only minutes of training by using a simple point-and-shoot approach to treatment application, akin to taking a cell phone photo

SAPRA™ is designed to maximize patient comfort. Non-contact optics eliminate the need for corneal contact lenses, eye drops or dilation. Treatment takes only seconds. Human factors engineering enhances patient accessibility and comfort, fostering compliance with the Vision Protection Therapy™ treatment program of regular periodic SDM™ designed to maintain the benefits of treatment initially and over a period of time.

The Outcomes of Applied Vision Protection Therapy™

Hormesis is one of the most important emerging sciences in medicine and the key to preventing aging and chronic disease. Retinal Thermal Hormesis ("RhyTHm") describes the way SAPRA™-applied SDM™ Vision Protection Therapy™ activates this powerful universal biologic process of cellular restoration and rejuvenation to reverse cellular aging, stop degeneration, and decrease chronic inflammation.

Targeted drug therapy seeks to overcome biologic complexity. Because of this complexity, it is seldom safe and effective even for a narrow range of applications. SAPRA™-applied SDM™ Vision Protection Therapy™ instead leverages biologic complexity via adaptive thermal hormesis to produce a physiologic "reset", normalizing retinal function. SDM™ Vision Protection Therapy™ is thus universally and robustly both safe and effective over a wide range of applications.

Key Clinical Publications

Age-Related Macular Degeneration

Luttrull, J. K., & Gray, G. (2022). Real World Data Comparison of Standard Care vs SDM Laser Vision Protection Therapy for Prevention of Neovascular AMD.

Clin Ophthalmol., 16, 1555-1568.

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Geographic Atrophy

Luttrull, J. K., Sinclair, S. H., Elmann, S., Chang, D. B., & Kent, D. (2020). Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser.

Clin Ophthalmol., 14, 2983-2993.

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Open Angle Glaucoma

Luttrull JK, Tzekov R, Bhavan SV. (2024). Progressive Thickening of Retinal Nerve Fiber and Ganglion Cell Complex Layers Following SDM Laser Vision Protection Therapy in Open-Angle Glaucoma.

Ophthalmol Ther., 13(11):2903-2918.

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Retinitis Pigmentosa

Luttrull JK. (2018). Improved Retinal and Visual Function Following Panmacular Subthreshold Diode Micropulse Laser for Retinitis Pigmentosa.

Eye (London). 32(6):1099-1110.

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Diabetic Macular Edema

Luttrull JK, Musch DC, Mainster MA. (2005). Subthreshold Diode Micropulse Photocoagulation for the Treatment of Clinically Significant Diabetic Macular Edema.

Br Journal Ophthalmol. 89(1):74-80.

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